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  • canstockphoto6244971

    Febrile neutropenia is a common,
    life-threatening
    complication of chemotherapy

  • canstockphoto62820667

    Gut barrier Injury and Neutrophil
    depletion puts patients at risk for
    bacteremia and sepsis

  • canstockphoto7427952

    AKTHELIA'S DRUG CANDIDATE KNOCKS OUT
    BACTERAEMIA BY STRENGTHENING
    INNATE GUT BARRIER DEFENSES

  • N1WT6iuIb

    eliminating the need for prophylactiC antibiotics

  • V1fz3suL-

    reducing risk of serious adverse events,
    antimicrobial resistance and
    microbiome dysbiosis

Second close of follow-up round

Additional 27 MISK secured after in-vivo validation

June 29, 2022

The second close of Akthelia's closed follow-up bridge funding round was over twice oversubscribed. Akthelia will now continue laying the necessary groundwork pursue funding for pre-IND enabling and Phase 1 studies..

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Grant from Cancer Society

Akthelia founder awarded

June 6, 2022

Akthelia's founder Guðmundur Hrafn Guðmundsson was recently awarded a grant from the Icelandic Cancer Society to fund research into prophylactic therapies for febrile neutropenia..

More information on the Society's web site.

Lesa meira

Lancet: AMR leading cause of death worldwide

Antimicrobial Resistance estimated death toll 1,29 million in 2019

January 21, 2022
A comprehensive analysis of global impact of antimicrobial resistance (AMR) in 2019 estimates resistance itself caused 1.27 million deaths, and that antimicrobial-resistant infections played a role in 4.95 million deaths. Estimates for 204 countries and territories confirm AMR as a global health threat, with worst impacts in low- and middle-income countries (LMICs), though higher income countries also face alarmingly high levels of AMR.

Rapid investment in new treatments, improved infection control measures, and optimised use of antibiotics are among the measures that can help countries protect their health systems against the threat of AMR.

The analysis of 204 countries and territories, published in The Lancet, reveals that AMR is now a leading cause of death worldwide, higher than HIV/AIDS or malaria. It shows that many hundreds of thousands of deaths now occur due to common, previously treatable infections – such as lower respiratory and bloodstream infections – because the bacteria that cause them have become resistant to treatment. The report highlights an urgent need to scale up action to combat AMR, and outlines immediate actions for policymakers that will help save lives and protect health systems. These include optimising the use of existing antibiotics, taking greater action to monitor and control infections, and providing more funding to develop new antibiotics and treatments.
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Follow-up pre-seed equity round

27 MISK secured to validate in-vivo results

January 1, 2022

Akthelia has secured a closed follow-up bridge funding round. 12 existing shareholders, bought shares for a total of 27 mISK.

The plan for the investment is to conduct further animal studies, define target product profile and position the company to be institutional investor ready.

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New employee

September 1, 2021

Akthelia has enlisted Steingrímur Stefánsson in the role of Senior Scientist. Steingrímur (Stenni) finished a Ph.D. Degree in molecular biochemistry from Virginia Commonwealth University in 1990 and has worked in senior roles for various biotech companies in the US since then. 

He has extensive experience in protein purification, protein modifications, protein-protein interactions, proteinases, their inhibitors. 

He also has a wide experience in cancer cell biology and assay development https://www.researchgate.net/profile/Steingrimur-Stefansson

Lesa meira

AKthelia awarded a RANNÍS grant

Novel wound healing approach

June 1, 2021

Akathelia together with co-founder prof. Guðmundur Hrafn Guðmundsson has been awarded a RANNÍS grant from the Applied Research projects (Hagnýt rannsóknarverkefni) for the initial development of a novel wound healing technology. The total grant amounts to 45 mISK over three years.

Lesa meira

Akthelia closes a pre-seed equity round

42 mISK secured in angel round

September 1, 2020

Akthelia has closed an angel-led funding round. 12 new shareholders, many of whom are angel investors with pharma industry background, bought shares for a total of 31,5 mISK. In addition, Nýsköpunarsjóður atvinnulífsins extended and converted a bond amounting to 10,8 mISK to shares, bringing the total round to just over 42 mISK. 

We would like to thank the new shareholders for their trust and for joining us on our journey. Many of the new shareholders have a background in pharmaceutics and bring a valuable network along. The plan for the investment is to fund immediate value increasing activities for Akthelia, including preliminary tox and PK for AKT-013 and achieving proof of concept in an established animal model. However, in June 2019 RANNÍS selected Akthelia for a grant from their Vöxtur program. Total grant is 46 mISK over two years.  

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AKthelia awarded a RANNÍS grant

46 mISK to develop proof of concept

June 15, 2019

RANNÍS has awarded Akthelia a grant from their Vöxtur program. Total grant is 46 mISK over two years. This grant increases greatly the scope of Akthelia’s development program. Akthelia’s main current goal is to show proof of concept in an established animal infection model. 

Akthelia has developed and patented a class of small molecules that modulate the body’s innate immunity, leading to elimination of bacteria and clearing of infections. Instead of administering antibiotics, Akthelia’s approach acts like a switch that turns on our innate antimicrobial defences and strengthens epithelial cell walls and has been shown to work against multiple pathogens, including resistant ones. The compounds might constitute the first broad spectrum antibiotic that does not negatively impact the body’s internal bacterial flora.

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Antimicrobial Peptides 2019, Gordon Research Conference

Akthelia strongly represented at this scientific conference

January 28, 2019

The focus of the 2019 Gordon Conference on Antimicrobial Peptides is utilizing our knowledge of mechanisms of AMP action, and mining species diversity to advance application to global infection challenges, including the threat of antimicrobial resistance, and sharing experience of translating fundamental research to commercial development and clinical practice.

Akthelia is strongly represented at this conference.

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New substances are treating infections by activating the immune system

Interview with Peter Bergman

January 15, 2019
2018, Peter Bergman, Akthelia's clinical advisor, received research support from the Swedish Foundation To Prevent Antibiotic Resistance. The foundation's website featured an interview with Peter which can be found here.
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AKTHELIA SELECTED AS FINALIST FOR THE SCIENCE 2 STARTUP EVENT

February 27, 2018
Akthelia has been selected as a finalist for the Science 2 Startup event which will be held in Cambridge, Massachusetts in April. This will be an all-day symposium with a keynote speaker, poster sessions, and panel discussions to help facilitate better relationships between PIs / TTOs and investors in the biotech community. https://www.science2startup.com/ 
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NEW ARTICLE ON TREATING CHOLERA WITH ONE OF THE APD'S

June 15, 2017
Sarker P, Banik A, Stromberg R, Gudmundsson GH, Raqib R, Agerberth B. 2017. Treatment with Entinostat Heals Experimental Cholera by Affecting Physical and Chemical Barrier Functions of Intestinal Epithelia. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02570-16. doi:10.1128/AAC.02570-16. Print 2017 Jul. PMID: 28438947
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